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Given the smaller sample sizes available in non-European populations, we did not perform genome-wide association testing in these populations, and instead focused analyses on variants discovered as associated in the European GWAS

This helps match sulfur, amino, carboxyl, or orthogonal-handle chemistry to the actual structural goal of the project

Trials suggest its side effect profile looks a lot like whats been seen with other GLP-1 drugs like Wegovy and Zepbound

Silica nanoparticles coated with polydopamine exhibit pH-sensitive mucus penetration, with diffusion rates approximately three times higher at pH 5.6 close to their isoelectric point than at more acidic (pH 3) or neutral (pH 7) conditions 184,185